Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome.
Publication/Presentation Date
8-1-2022
Abstract
BACKGROUND: Cardiac troponin (cTn) can be elevated in many patients presenting to the emergency department (ED) with chest pain but without a diagnosis of acute coronary syndrome (ACS). We compared the prognostic significance of cTn in these different populations.
METHODS: We retrospectively analyzed the CHOPIN study, which enrolled patients who presented to the ED with chest pain. Patients were grouped as ACS, non-ACS cardiovascular disease, noncardiac chest pain and chest pain not otherwise specified (NOS). We examined the prognostic ability of cTnI for the clinical endpoints of mortality and major adverse cardiovascular event (MACE; a composite of acute myocardial infarction, unstable angina, revascularization, reinfarction, and congestive heart failure and stroke) at 180-day follow-up.
RESULTS: Among 1982 patients analyzed, 14% had ACS, 21% had non-ACS cardiovascular disease, 31% had a noncardiac diagnosis and 34% had chest pain NOS. cTnI elevation above the 99th percentile was observed in 52, 18, 6 and 7% in these groups, respectively. cTnI elevation was associated with mortality and MACE, and their relationships were more prominent in noncardiac diagnosis and chest pain NOS than in ACS and non-ACS cardiovascular diagnoses for mortality, and in non-ACS patients than in ACS patients for MACE (hazard ratio for doubling of cTnI 1.85, 2.05, 8.26 and 4.14, respectively; P for interaction 0.011 for mortality; 1.04, 1.23, 1.54 and 1.42, respectively; P for interaction < 0.001 for MACE).
CONCLUSION: In patients presenting to the ED with chest pain, cTnI elevation was associated with a worse prognosis in non-ACS patients than in ACS patients.
Volume
33
Issue
5
First Page
376
Last Page
384
ISSN
1473-5830
Published In/Presented At
Horiuchi, Y., Wettersten, N., Patel, M. P., Mueller, C., Neath, S. X., Christenson, R. H., Morgenthaler, N. G., McCord, J., Nowak, R. M., Vilke, G. M., Daniels, L. B., Hollander, J. E., Apple, F. S., Cannon, C. M., Nagurney, J. T., Schreiber, D., deFilippi, C., Hogan, C., Diercks, D. B., Headden, G., … Maisel, A. (2022). Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coronary artery disease, 33(5), 376–384. https://doi.org/10.1097/MCA.0000000000001135
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
35880560
Department(s)
Administration and Leadership
Document Type
Article