Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis.
Publication/Presentation Date
10-1-2008
Abstract
Apoptosis has been implicated as an important process in the development of several organ systems, including limbs, kidneys, and the heart. In developing murine lungs, the authors found that apoptosis was more predominant during the pseudoglandular stage of lung development than during the saccular stage, with 93% of the apoptotic structures in the mesenchyme. Murine lung explants cultured in the presence of zinc chloride and aurintricarboxylic acid, 2 blockers of endonuclease function, showed decreased branching. These observations suggest that apoptosis predominates in mesenchymal cells during the pseudoglandular stage of lung development, and may be important for normal progression of lung branching morphogenesis.
Volume
34
Issue
8
First Page
481
Last Page
499
ISSN
1521-0499
Published In/Presented At
Wongtrakool, C., & Roman, J. (2008). Apoptosis of mesenchymal cells during the pseudoglandular stage of lung development affects branching morphogenesis. Experimental lung research, 34(8), 481–499. https://doi.org/10.1080/01902140802271842
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18850375
Department(s)
Administration and Leadership
Document Type
Article