Peroxisome proliferator-activated receptors in lung cancer.
Publication/Presentation Date
1-1-2007
Abstract
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. Their discovery in the 1990s provided insights into the cellular mechanisms involved in the control of energy homeostasis; the regulation of cell differentiation, proliferation, and apoptosis; and the modulation of important biological and pathological processes related to inflammation, among others. Since then, PPARs have become an exciting therapeutic target for several diseases. PPARs are expressed by many tumors including lung carcinoma cells, and their function has been linked to the process of carcinogenesis in lung. Consequently, intense research is being conducted in this area with the hope of discovering new PPAR-related therapeutic targets for the treatment of lung cancer. This review summarizes the research being conducted in this area and focuses on the mechanisms by which PPARs are believed to affect lung tumor cell biology.
Volume
2007
First Page
90289
Last Page
90289
ISSN
1687-4757
Published In/Presented At
Keshamouni, V. G., Han, S., & Roman, J. (2007). Peroxisome proliferator-activated receptors in lung cancer. PPAR research, 2007, 90289. https://doi.org/10.1155/2007/90289
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18274632
Department(s)
Administration and Leadership
Document Type
Article