Age-dependent oxidation of extracellular cysteine/cystine redox state (E

Authors

• Yuxuan Zheng
• Jeffrey D Ritzenthaler
• Tom J Burke
• Javier Otero
• Jesse Roman
• Walter H Watson

Publication/Presentation Date

4-1-2018

Abstract

Aging is associated with progressive oxidation of the extracellular environment. The redox state of human plasma, defined by the concentrations of cysteine (Cys) and cystine (CySS), becomes more oxidized as we age. Recently, we showed that fibroblasts isolated from the lungs of young and old mice retain this differential phenotype; old cells produce and maintain a more oxidizing extracellular redox potential (E

Volume

118

First Page

13

Last Page

22

ISSN

1873-4596

Published In/Presented At

Zheng, Y., Ritzenthaler, J. D., Burke, T. J., Otero, J., Roman, J., & Watson, W. H. (2018). Age-dependent oxidation of extracellular cysteine/cystine redox state (Eh(Cys/CySS)) in mouse lung fibroblasts is mediated by a decline in Slc7a11 expression. Free radical biology & medicine, 118, 13–22. https://doi.org/10.1016/j.freeradbiomed.2018.02.026

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

29458149

Department(s)

Administration and Leadership

Document Type

Article