Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice.

Authors

• Lauren G Poole
• Veronica L Massey
• Deanna L Siow
• Edilson Torres-Gonzáles
• Nikole L Warner
• James P Luyendyk
• Jeffrey D Ritzenthaler
• Jesse Roman
• Gavin E Arteel

Publication/Presentation Date

9-1-2017

Abstract

Chronic alcohol exposure is a clinically important risk factor for the development of acute respiratory distress syndrome, the most severe form of acute lung injury (ALI). However, the mechanisms by which alcohol sensitizes the lung to development of this disease are poorly understood. We determined the role of the antifibrinolytic protein plasminogen activator inhibitor-1 (PAI-1) in alcohol enhancement of experimental endotoxin-induced ALI. Wild-type, PAI-1

Volume

57

Issue

3

First Page

315

Last Page

323

ISSN

1535-4989

Published In/Presented At

Poole, L. G., Massey, V. L., Siow, D. L., Torres-Gonzáles, E., Warner, N. L., Luyendyk, J. P., Ritzenthaler, J. D., Roman, J., & Arteel, G. E. (2017). Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. American journal of respiratory cell and molecular biology, 57(3), 315–323. https://doi.org/10.1165/rcmb.2016-0184OC

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

28445073

Department(s)

Administration and Leadership

Document Type

Article