Sex-Based Differences in Interstitial Lung Disease.
Publication/Presentation Date
11-1-2020
Abstract
Interstitial lung diseases comprise a family of progressive pulmonary disorders that are often idiopathic or associated with various systemic diseases and that is characterized by bilateral lung involvement with inflammation and tissue remodeling or fibrosis. The impact of sex, including the anatomic and physiologic traits that one is born with, on the development and progression of interstitial lung diseases is not entirely clear. Variances between men and women are driven by differences in male and female biology and sex hormones, among other differences, but their role remains uncertain. In this review, we summarize sex-related differences in the epidemiology and progression of certain interstitial lung diseases with a focus on the connective tissue related interstitial lung diseases, idiopathic pulmonary fibrosis, and sarcoidosis. We also discuss cellular and pre-clinical studies that might shed light on the potential mechanisms responsible for these differences in the hope of unveiling potential targets for intervention and stimulating research in this needed field of investigation.
Volume
360
Issue
5
First Page
467
Last Page
473
ISSN
1538-2990
Published In/Presented At
Pandit, P., Perez, R. L., & Roman, J. (2020). Sex-Based Differences in Interstitial Lung Disease. The American journal of the medical sciences, 360(5), 467–473. https://doi.org/10.1016/j.amjms.2020.04.023
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
32487327
Department(s)
Administration and Leadership
Document Type
Article