Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry.
Publication/Presentation Date
10-22-2019
Abstract
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development. We sought to quantify the circulating proteome in IPF, determine differential protein expression between subjects with IPF and controls, and examine relationships between protein expression and markers of disease severity.
METHODS: This study involved 300 patients with IPF from the IPF-PRO Registry and 100 participants without known lung disease. Plasma collected at enrolment was analysed using aptamer-based proteomics (1305 proteins). Linear regression was used to determine differential protein expression between participants with IPF and controls and associations between protein expression and disease severity measures (percent predicted values for forced vital capacity [FVC] and diffusion capacity of the lung for carbon monoxide [DLco]; composite physiologic index [CPI]). Multivariable models were fit to select proteins that best distinguished IPF from controls.
RESULTS: Five hundred fifty one proteins had significantly different levels between IPF and controls, of which 47 showed a |log
CONCLUSIONS: Patients with IPF have a distinct circulating proteome and can be distinguished using a nine-protein profile. Several proteins strongly associate with disease severity. The proteins identified may represent biomarker candidates and implicate pathways for further investigation.
TRIAL REGISTRATION: ClinicalTrials.gov (NCT01915511).
Volume
20
Issue
1
First Page
227
Last Page
227
ISSN
1465-993X
Published In/Presented At
Todd, J. L., Neely, M. L., Overton, R., Durham, K., Gulati, M., Huang, H., Roman, J., Newby, L. K., Flaherty, K. R., Vinisko, R., Liu, Y., Roy, J., Schmid, R., Strobel, B., Hesslinger, C., Leonard, T. B., Noth, I., Belperio, J. A., Palmer, S. M., & IPF-PRO Registry investigators (2019). Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry. Respiratory research, 20(1), 227. https://doi.org/10.1186/s12931-019-1190-z
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31640794
Department(s)
Administration and Leadership
Document Type
Article