Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients.
Publication/Presentation Date
11-1-2019
Abstract
Chronic obstructive pulmonary disease (COPD) is prevalent in patients infected with HIV. The purpose of this study was to test the hypothesis that systemic oxidation correlates with loss of lung function in subjects with COPD, and that HIV infection can contribute to creating such an environment. Subjects were recruited at the University of Louisville in the following groups: HIV-infected (n = 36), COPD (n = 32), HIV and COPD (n = 28), and uninfected controls with normal lung function (n = 34). HIV infection was assessed by viral load and CD4 cell counts. Pulmonary function was determined by spirometry, and plasma was collected for measurement of cysteine (Cys), cystine (CySS), glutathione (GSH) and GSH disulfide (GSSG) by HPLC followed by estimation of redox potentials (E
Volume
143
First Page
55
Last Page
61
ISSN
1873-4596
Published In/Presented At
Watson, W. H., Ritzenthaler, J. D., Peyrani, P., Wiemken, T. L., Furmanek, S., Reyes Vega, A. M., Burke, T. J., Zheng, Y., Ramirez, J. A., & Roman, J. (2019). Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients. Free radical biology & medicine, 143, 55–61. https://doi.org/10.1016/j.freeradbiomed.2019.07.031
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31369840
Department(s)
Administration and Leadership
Document Type
Article