DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo.
Publication/Presentation Date
2-1-2008
Abstract
Non-homeostatic tissue apoptosis in vivo has been shown to induce inflammatory responses and facilitate the cross-presentation of proteins within apoptotic bodies. We hypothesize that in the presence of foreign antigens, the apoptotic-inflammatory process improves immune priming; further, molecules that trigger apoptosis may be adapted for use as immune adjuvants. One very attractive molecule in this context is the tumor necrosis factor receptor (TNFR) family molecule DR5/TRAIL-receptor 2. We show a significant improvement in CD8(+) T-cell mediated vaccine immunity with the use of death receptor-5 (DR5) as an immune adjuvant, a property that is correlated with the activation of caspases-8 (casp8) and dependent on its ability to induce apoptosis in vivo.
Volume
16
Issue
2
First Page
419
Last Page
426
ISSN
1525-0024
Published In/Presented At
Chattergoon, M. A., Muthumani, K., Tamura, Y., Ramanathan, M., Shames, J. P., Saulino, V., Robinson, T. M., Montaner, L. J., & Weiner, D. B. (2008). DR5 activation of caspase-8 induces DC maturation and immune enhancement in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 16(2), 419–426. https://doi.org/10.1038/sj.mt.6300373
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
18087262
Department(s)
Administration and Leadership
Document Type
Article