Sequential exposure to histological chorioamnionitis and postnatal hyperoxia alters gene expression in cord blood monocytes.
Publication/Presentation Date
1-1-2026
Abstract
BACKGROUND: Sequential exposure to heterologous noxious stimuli such as histological chorioamnionitis (HCA) and hyperoxia may elicit variable immune responses, resulting in distinct disease manifestations in the neonate. However, the molecular mechanisms underlying innate immune dysregulation in these contexts remain poorly characterized.
METHODS: We conducted a pilot prospective observational study evaluating global gene expression in cord blood monocytes obtained from term infants born to mothers with and without HCA. Monocytes were exposed
RESULTS: We studied monocytes from 14 neonates (HCA
CONCLUSIONS: Sequential exposure to histological chorioamnionitis and postnatal hyperoxia induces alterations in gene expression and molecular pathways in neonatal cord blood monocytes, affecting immune regulation, which could potentially contribute to the pathogenesis of short- and long-term diseases.
Volume
14
First Page
1896464
Last Page
1896464
ISSN
2296-2360
Published In/Presented At
Sequeira Gomes, R., Gayen Nee' Betal, S., Addya, S., Gayen, S., Zubair, N., Chan, J. S. Y., & Aghai, Z. H. (2026). Sequential exposure to histological chorioamnionitis and postnatal hyperoxia alters gene expression in cord blood monocytes. Frontiers in pediatrics, 14, 1896464. https://doi.org/10.3389/fped.2026.1896464
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
42812615
Department(s)
Administration and Leadership
Document Type
Article