Frank Stinchfield Award. Titanium surface with biologic activity against infection.

Authors

• Javad Parvizi
• Eric Wickstrom
• Allen R Zeiger
• Christopher S Adams
• Irving M Shapiro
• James J Purtill
• Peter F Sharkey
• William J Hozack
• Richard H Rothman
• Noreen J Hickok

Publication/Presentation Date

12-1-2004

Abstract

Despite immense improvements, periprosthetic infection continues to compromise the result of otherwise successful joint arthroplasty. There are various limitations in the treatment of periprosthetic infection, the most important of which is the inability to deliver antibiotics to the local tissue without the need for intravenous administration. We have developed a novel route to covalently tether vancomycin to a metal (titanium) surface, which showed effective bactericidal activity because of a vancomycin coupling. The chemistry of tethering does not affect the biological activity of the biofactors that are attached to the metal surface. This technology holds great promise for the manufacturing of "smart" implants that can be self protective against periprosthetic infection, or can be used for the treatment of periprosthetic infections when they occur.

Issue

429

First Page

33

Last Page

38

ISSN

0009-921X

Published In/Presented At

Parvizi, J., Wickstrom, E., Zeiger, A. R., Adams, C. S., Shapiro, I. M., Purtill, J. J., Sharkey, P. F., Hozack, W. J., Rothman, R. H., & Hickok, N. J. (2004). Frank Stinchfield Award. Titanium surface with biologic activity against infection. Clinical orthopaedics and related research, (429), 33–38. https://doi.org/10.1097/01.blo.0000150116.65231.45

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

15577462

Department(s)

Administration and Leadership

Document Type

Article