Patients on Losartan Have Similar Rates of Manipulation Under Anesthesia After Total Knee Arthroplasty.

Authors

• Benjamin Miltenberg
• Alexander Linton
• Elizabeth Abe
• Brandon J Martinazzi
• Gabriel Furey
• William L Johns
• Matthew B Sherman
• James J Purtill
• Eric B Smith

Publication/Presentation Date

8-1-2025

Abstract

Introduction Patients have identified knee stiffness as a factor contributing to postoperative dissatisfaction after total knee arthroplasty (TKA). Losartan is an angiotensin receptor blocker (ARB) that has demonstrated antifibrotic effects; however, the impact of perioperative losartan on arthrofibrosis after TKA is not well understood. Therefore, the purpose of this study was to determine if losartan exhibits antifibrotic benefits in patients who undergo TKA by decreasing the rates of manipulation under anesthesia (MUA), when compared to patients who are not taking losartan. Methods All patients who underwent primary TKA by fellowship-trained arthroplasty surgeons at a single institution from January 1

Volume

17

Issue

8

First Page

89572

Last Page

89572

ISSN

2168-8184

Published In/Presented At

Miltenberg, B., Linton, A., Abe, E., Martinazzi, B. J., Furey, G., Johns, W. L., Sherman, M. B., Purtill, J. J., & Smith, E. B. (2025). Patients on Losartan Have Similar Rates of Manipulation Under Anesthesia After Total Knee Arthroplasty. Cureus, 17(8), e89572. https://doi.org/10.7759/cureus.89572

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

40922856

Department(s)

Administration and Leadership

Document Type

Article