Carcinomatous Transformation of Odontogenic Keratocyst and Primary Intraosseous Carcinoma: A Systematic Review and Report of a Case.

Publication/Presentation Date

5-1-2021

Abstract

PURPOSE: To assess the prognostic findings of the carcinomatous transformation of odontogenic keratocyst (OKC).

METHODS: A systematic review of all cases of carcinomatous transformation of OKC was completed, and a case report was included.

RESULTS: A total of 679 publications were screened, and 37 cases met inclusion criteria. The mean age for patients with malignant transformation of OKC was 45.1 years. Pain (67.5%) and swelling (78.3%) were the most common symptoms. The malignant transformation occurred with increased frequency in the posterior mandible and larger lesions that span greater than 2 subunits of the involved jaw. Resection was the definitive treatment in all cases and 14 cases (46%) utilized adjuvant treatment.

CONCLUSIONS: Patient outcomes and follow-up was variable in our study such that overall survival was difficult to determine. However, overall survival in malignant transformation of odontogenic cysts of all kinds ranges from 62 to 85% and 30 to 8% for 2 and 5 years, respectively.

Volume

79

Issue

5

First Page

1

Last Page

1081

ISSN

1531-5053

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

33529609

Department(s)

Administration and Leadership

Document Type

Article

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