REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers.

Authors

• Rachel Saunders-Pullman
• Roy N Alcalay
• Anat Mirelman
• Cuiling Wang
• Marta San Luciano
• Roberto A Ortega
• Amanda Glickman
• Deborah Raymond
• Helen Mejia-Santana
• Nancy Doan
• Brooke Johannes
• Kira Yasinovsky
• Laurie Ozelius
• Lorraine Clark
• Avi Orr-Utreger
• Karen Marder
• Nir Giladi
• Susan B Bressman

Publication/Presentation Date

11-1-2015

Abstract

BACKGROUND: Rapid eye movement sleep behavior disorder occurs with idiopathic Parkinson's disease (PD) and often precedes PD. Its frequency in LRRK2-PD and utility as a preclinical marker has not been established.

METHODS: One hundred forty-four idiopathic PD, 142 LRRK2 G2019S mutation PD, 117 non-manifesting carriers, 93 related noncarriers, and 40 healthy controls completed the Rapid eye movement sleep Behavior Disorder Screening Questionnaire.

RESULTS: Cut scores were met by 30.6% idiopathic PD, 19.7% LRRK2-PD, 6% nonmanifesting carriers, 20.4% related noncarriers, and 15% controls. The likelihood of abnormal scores was decreased in LRRK2-PD versus idiopathic PD (odds ratio = 0.55, P = 0.03), nonmanifesting carriers versus related noncarriers (OR = 0.25, P < 0.01), and PD of less than 3 years' duration, 1 of 19 LRRK2-PD versus 14 of 41 idiopathic PD (P < 0.05).

CONCLUSIONS: A lower frequency of abnormal questionnaire scores is seen in LRRK2-PD, especially in early LRRK2-PD, and in nonmanifesting carriers. Therefore, the Rapid eye movement sleep Behavior Disorder Questionnaire is unlikely to serve as a preclinical marker for phenoconversion to PD.

Volume

30

Issue

13

First Page

1834

Last Page

1839

ISSN

1531-8257

Published In/Presented At

Saunders-Pullman, R., Alcalay, R. N., Mirelman, A., Wang, C., Luciano, M. S., Ortega, R. A., Glickman, A., Raymond, D., Mejia-Santana, H., Doan, N., Johannes, B., Yasinovsky, K., Ozelius, L., Clark, L., Orr-Utreger, A., Marder, K., Giladi, N., Bressman, S. B., & AJ LRRK2 Consortium (2015). REM sleep behavior disorder, as assessed by questionnaire, in G2019S LRRK2 mutation PD and carriers. Movement disorders : official journal of the Movement Disorder Society, 30(13), 1834–1839. https://doi.org/10.1002/mds.26413

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

26366513

Department(s)

Administration and Leadership

Document Type

Article