Cutaneous B-Cell Lymphoblastic Lymphoma.
Publication/Presentation Date
8-1-2019
Abstract
B-cell lymphoblastic lymphoma (B-LBL) is a malignant neoplasm of immature B cells that accounts for only 10% of all cases of lymphoblastic lymphoma. Most commonly, B-LBL presents as bony lesions, but in rare cases, the disease manifests cutaneously. We present a case of simultaneous cutaneous and systemic presentation of B-LBL in an otherwise healthy 28-year-old man in which the lymphoblastic infiltrate stained positive for CD79a, Tdt, CD10, and CD20. A diagnosis of cutaneous B-LBL was made, and systemic work-up revealed widespread involvement of the skin, bone, and lymph nodes. Review of all currently described cases of cutaneous B-LBL with or without systemic involvement revealed that the most frequently positive tumor markers were CD79a (92.3%), Tdt (90.6%), and CD10 (83.3%). Systemic involvement of B-LBL was found in nearly half of all cases with cutaneous presentation.
Volume
41
Issue
8
First Page
596
Last Page
601
ISSN
1533-0311
Published In/Presented At
Amarasekera, D., Connolly, D., Gochoco, A., Yang, S., Grosso, D., Flomenberg, N., Shi, W., Alpdogan, S. O., Duffy, R., & Sahu, J. (2019). Cutaneous B-Cell Lymphoblastic Lymphoma. The American Journal of dermatopathology, 41(8), 596–601. https://doi.org/10.1097/DAD.0000000000001347
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
31335415
Department(s)
Administration and Leadership
Document Type
Article