The Nephrotoxicity of Vancomycin.
Publication/Presentation Date
9-1-2017
Abstract
Vancomycin use is often associated with nephrotoxicity. It remains uncertain, however, to what extent vancomycin is directly responsible, as numerous potential risk factors for acute kidney injury frequently coexist. Herein, we critically examine available data in adult patients pertinent to this question. We review the pharmacokinetics/pharmacodynamics of vancomycin metabolism. Efficacy and safety data are discussed. The pathophysiology of vancomycin nephrotoxicity is considered. Risk factors for nephrotoxicity are enumerated, including the potential synergistic nephrotoxicity of vancomycin and piperacillin-tazobactam. Suggestions for clinical practice and future research are given.
Volume
102
Issue
3
First Page
459
Last Page
469
ISSN
1532-6535
Published In/Presented At
Filippone, E. J., Kraft, W. K., & Farber, J. L. (2017). The Nephrotoxicity of Vancomycin. Clinical pharmacology and therapeutics, 102(3), 459–469. https://doi.org/10.1002/cpt.726
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
28474732
Department(s)
Administration and Leadership
Document Type
Article