Ethanol pharmacokinetics in neonates and infants.
Publication/Presentation Date
12-1-2014
Abstract
INTRODUCTION: Ethanol has been used for years in neonatal and infant liquid medications, yet the pharmacokinetics, pharmacodynamics, and safety of ethanol in this vulnerable population have not been well characterized. The purpose of this review is to raise awareness of ethanol use as an excipient in neonatal and infant medications and to provide insight, based on the available evidence, into clearance rates of ethanol in babies. We also discuss ethanol pharmacokinetics in adults, theoretical pharmacokinetic changes in neonates and infants as it may apply to ethanol disposition, and case reports involving ethanol exposure in neonates and infants.
MATERIALS AND METHODS: This study was a narrative review in which relevant papers were selected using databases and scientific search engines such as PubMed with the key words ethanol, infant, and newborn infant.
RESULTS: It remains unclear what ethanol exposure is safe for neonates and infants. The Food and Drug Administration and American Academy of Pediatrics have both taken action, by either setting limits of ethanol content in over-the-counter medications or by recommending restricted exposure to ethanol-containing pediatric formulations.
CONCLUSIONS: Until the short- and long-term health effects of chronic ethanol administration can be further characterized, ethanol-containing medications should be used with caution.
Volume
76
First Page
90
Last Page
97
ISSN
0011-393X
Published In/Presented At
Marek, E., & Kraft, W. K. (2014). Ethanol pharmacokinetics in neonates and infants. Current therapeutic research, clinical and experimental, 76, 90–97. https://doi.org/10.1016/j.curtheres.2014.09.002
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25379066
Department(s)
Administration and Leadership
Document Type
Article