Clinical and demographic predictors of the need for pharmacotherapy in neonatal abstinence syndrome.

Authors

• Shawana Bibi
• Rachana Singh
• Janis L Breeze
• Jason Nelson
• Walter K Kraft
• Jonathan M Davis

Publication/Presentation Date

1-1-2025

Abstract

OBJECTIVE: Development and validation of a clinical prediction model for receipt of pharmacotherapy for Neonatal Abstinence Syndrome (NAS).

STUDY DESIGN: Data from three cohorts included

RESULTS: Of 698 infants included, 430 received pharmacotherapy. The final model included seven predictors of receipt of pharmacotherapy: gestational age, exposure to maternal breast milk, type of maternal opioid medication, and exposure to heroin, cocaine, benzodiazepines, and/or antipsychotic medications. The model had an AUROC of 0.68 (95% CI: 0.64-0.72; optimism corrected 0.65).

CONCLUSION: Our prediction model was parsimonious and identified seven predictors associated with the need for PT. Larger cohort studies are needed to more definitively establish risk of significant NAS requiring pharmacotherapy.

Volume

13

First Page

1527276

Last Page

1527276

ISSN

2296-2360

Published In/Presented At

Bibi, S., Singh, R., Breeze, J. L., Nelson, J., Kraft, W. K., & Davis, J. M. (2025). Clinical and demographic predictors of the need for pharmacotherapy in neonatal abstinence syndrome. Frontiers in pediatrics, 13, 1527276. https://doi.org/10.3389/fped.2025.1527276

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

40861052

Department(s)

Administration and Leadership

Document Type

Article