Abstinence scoring algorithms for treatment of neonatal opioid withdrawal syndrome (NOWS).
Publication/Presentation Date
8-1-2024
Abstract
OBJECTIVE: Chervoneva et al. (2020) developed an abbreviated score (sMNAS-9) derived from full modified Finnegan MOTHER NAS scale (MNAS) for evaluating severity of NOWS. We sought to develop NOWS treatment algorithms for clinical decision rules based on scores utilizing the shorter sMNAS.
STUDY DESIGN: This was a retrospective study of 373 infants with NOWS scored with MNAS and treated with morphine between 2007 and 2016. The infants were randomly split into training/test sets. The training set was used to derive optimized cutoff values for sMNAS-9 scores. The independent set evaluated the sMNAS-9 clinical decision rules based on full MNAS in NOWS morphine and buprenorphine treatment algorithms.
RESULT: Clinical decision rules based on sMNAS-9 yielded sensitivities of 88% or higher and specificities of 85% or higher for predicting the respective rules based on full MNAS.
CONCLUSION: The sMNAS-9 scoring instrument is expected to yield similar clinical decisions in treatment of NOWS.
Volume
44
Issue
8
First Page
1132
Last Page
1136
ISSN
1476-5543
Published In/Presented At
Maisel, B. A., Adeniyi-Jones, S. C., Selvage, E., Ng, S., Kraft, W. K., & Chervoneva, I. (2024). Abstinence scoring algorithms for treatment of neonatal opioid withdrawal syndrome (NOWS). Journal of perinatology : official journal of the California Perinatal Association, 44(8), 1132–1136. https://doi.org/10.1038/s41372-024-01895-6
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
38366118
Department(s)
Administration and Leadership
Document Type
Article