Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants.
Publication/Presentation Date
3-1-2022
Abstract
Neonates born to mothers taking opioids during pregnancy are at risk for neonatal opioid withdrawal syndrome (NOWS), for which there is no recognized standard approach to care. Nonpharmacologic treatment is typically used as a first-line approach for management, and pharmacologic treatment is added when clinical signs are not responding to nonpharmacologic measures alone. Although morphine and methadone are the most commonly used pharmacotherapies for NOWS, buprenorphine has emerged as a treatment option based on its pharmacologic profile and results from initial single site clinical trials. The objective of this report is to provide an overview of NOWS including a summary of ongoing work in the field and to review the state of the science, knowledge gaps, and practical considerations specific to the use of buprenorphine for the treatment of NOWS as discussed by a panel of experts during a virtual workshop hosted by the National Institutes of Health.
Volume
42
Issue
3
First Page
300
Last Page
306
ISSN
1476-5543
Published In/Presented At
Devlin, L. A., Young, L. W., Kraft, W. K., Wachman, E. M., Czynski, A., Merhar, S. L., Winhusen, T., Jones, H. E., Poindexter, B. B., Wakschlag, L. S., Salisbury, A. L., Matthews, A. G., & Davis, J. M. (2022). Neonatal opioid withdrawal syndrome: a review of the science and a look toward the use of buprenorphine for affected infants. Journal of perinatology : official journal of the California Perinatal Association, 42(3), 300–306. https://doi.org/10.1038/s41372-021-01206-3
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
34556799
Department(s)
Administration and Leadership
Document Type
Article