"Embryonic" collagen (type I trimer) alpha 1-chains are genetically distinct from type I collagens alpha 1-chains.
Publication/Presentation Date
11-1-1982
Abstract
Our laboratory has previously demonstrated that cell lines derived from early embryonic mouse sources produce procollagen and collagen and suggested that this material represents a new genetic type of collagen. Evidence was presented using carboxymethyl cellulose chromatography, analytical isoelectric focusing, cyanogen bromide peptide analysis, amino acid analysis, and carbohydrate analysis which demonstrated that this "embryonic" collagen consisted of three identical alpha-chains, distinctly different from types I, II and III and IV collagen and thus probably represented a new type of collagen. Further evidence is presented using Staphylococcus aureus V-8 protease generated peptide maps and immunological studies using antisera prepared against "embryonic" collagen and procollagen. These data clearly demonstrated that "embryonic" collagen is clearly distinct from type I alpha-chains and represents a unique genetic species of collagen.
Volume
2
Issue
6
First Page
481
Last Page
494
ISSN
0174-173X
Published In/Presented At
Shupp-Byrne, D. E., & Church, R. L. (1982). "Embryonic" collagen (type I trimer) alpha 1-chains are genetically distinct from type I collagens alpha 1-chains. Collagen and related research, 2(6), 481–494. https://doi.org/10.1016/s0174-173x(82)80004-6
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
6762940
Department(s)
Administration and Leadership
Document Type
Article