Analyzing Antibiotic Usage Trends in Genitourinary Infections and Procedures: Insights From the TriNetX Database.

Authors

• Brian H Im
• Aaron R Hochberg
• Brandon Havranek
• Courtney E Capella
• Maria J D'Amico
• Analyse H Giordano
• Whitney Smith
• Alana Murphy
• Mihir S Shah
• Costas D Lallas

Publication/Presentation Date

3-1-2025

Abstract

OBJECTIVE: To analyze antibiotic prescribing trends, particularly the decline in fluoroquinolone use for various genitourinary infection (GUI) and procedures and the growing preference for alternative treatments.

METHODS: The TriNetX database was queried for antibiotic utilization rates from 2016 to 2022. We analyzed cases of cystitis, pyelonephritis, prostatitis, and other GUIs, as well as periprocedure utilization for benign prostatic hyperplasia, urethral stricture disease, pelvic organ prolapse/stress urinary incontinence, and overactive bladder/interstitial cystitis (OAB/IC). We determined the top four to six antibiotics prescribed within 5 days of diagnosis or procedure. Statistical analysis included linear regression modeling.

RESULTS: From 2016 to 2022, fluoroquinolone use decreased in cystitis (P < .001), pyelonephritis (P < .001), and prostatitis (P < .01). These infections were increasingly treated with beta-lactams (P < .0001, P < .01, P < .01, respectively). Additionally, we found a decrease in fluoroquinolone utilization in procedures for benign prostatic hyperplasia (P < .001), urethral stricture (P < .01), pelvic organ prolapse/stress urinary incontinence (P < .001), and OAB/IC (P < .001). All cohorts except for OAB/IC showed a significant increase in beta-lactam use (P < .001, P < .01, P < .01, respectively).

CONCLUSION: We noted a significant decline in fluoroquinolone use for GUI and procedures, accompanied by increased beta-lactam use, reflecting changes in prescribing practices. Judicious use is essential to promote antimicrobial stewardship and mitigate severe adverse effects.

Volume

197

First Page

20

Last Page

25

ISSN

1527-9995

Published In/Presented At

Im, B. H., Hochberg, A. R., Havranek, B., Capella, C. E., D'Amico, M. J., Giordano, A. H., Smith, W., Murphy, A., Shah, M. S., & Lallas, C. D. (2025). Analyzing Antibiotic Usage Trends in Genitourinary Infections and Procedures: Insights From the TriNetX Database. Urology, 197, 20–25. https://doi.org/10.1016/j.urology.2024.10.071

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

39522828

Department(s)

Administration and Leadership

Document Type

Article