Comparative outcomes of lung volume reduction surgery and lung transplantation: a systematic review and meta-analysis.

Publication/Presentation Date

7-31-2023

Abstract

BACKGROUND: Lung volume reduction (LVR) and lung transplantation (LTx) have been used in different populations of chronic obstructive pulmonary disease (COPD) patients. To date, comparative study of LVR and LTx has not been performed. We sought to address this gap by pooling the existing evidence in the literature.

METHODS: An electronic search was performed to identify all prospective studies on LVR and LTx published since 2000. Baseline characteristics, perioperative variables, and clinical outcomes were extracted and pooled for meta-analysis.

RESULTS: The analysis included 65 prospective studies comprising 3,671 patients [LTx: 15 studies (n=1,445), LVR: 50 studies (n=2,226)]. Mean age was 60 [95% confidence interval (CI): 58-62] years and comparable between the two groups. Females were 51% (95% CI: 30-71%) in the LTx group

CONCLUSIONS: LTx results in better FEV1 but otherwise has comparable outcomes to LVR.

Volume

15

Issue

7

First Page

3627

Last Page

3635

ISSN

2072-1439

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37559607

Department(s)

Administration and Leadership

Document Type

Article

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