Impact of Body Mass Index and Discomfort on Upper Airway Stimulation: ADHERE Registry 2020 Update.

Authors

• Maria V Suurna
• Armin Steffen
• Maurits Boon
• Eugene Chio
• Marcel Copper
• Reena Dhanda Patil
• Katherine Green
• Ronald Hanson
• Clemens Heiser
• Colin Huntley
• David Kent
• Christopher Larsen
• Shalini Manchanda
• Joachim T Maurer
• Ryan Soose
• Nico de Vries
• Harneet K Walia
• Erica Thaler

Publication/Presentation Date

11-1-2021

Abstract

OBJECTIVES/HYPOTHESIS: To provide the ADHERE registry Upper Airway Stimulation (UAS) outcomes update, including analyses grouped by body mass index (BMI) and therapy discomfort.

STUDY DESIGN: Prospective observational study.

METHODS: ADHERE captures UAS outcomes including apnea-hypopnea index (AHI), Epworth sleepiness scale (ESS), therapy usage, patient satisfaction, clinician assessment, and safety over a 1-year period. BMI ≤32 kg/m

RESULTS: One thousand eight hundred forty-nine patients enrolled in ADHERE, 1,019 reached final visit, 843 completed the visit. Significant changes in AHI (-20.9, P <  .0001) and ESS (- 4.4, P <  .0001) were demonstrated. Mean therapy usage was 5.6 ± 2.2 hr/day. Significant therapy use difference was present in patients with reported discomfort versus no discomfort (4.9 ± 2.5 vs. 5.7 ± 2.1 hr/day, P = .01). Patients with discomfort had higher final visit mean AHI versus without discomfort (18.9 ± 18.5 vs. 13.5 ± 13.7 events/hr, P = .01). Changes in AHI and ESS were not significantly different. Serious adverse events reported in 2.3% of patients. Device revision rate was 1.9%. Surgical success was less likely in BMI

CONCLUSIONS: Data from ADHERE demonstrate high efficacy rates for UAS. Although surgical response rate differs between BMI

LEVEL OF EVIDENCE: 4 Laryngoscope, 131:2616-2624, 2021.

Volume

131

Issue

11

First Page

2616

Last Page

2624

ISSN

1531-4995

Published In/Presented At

Suurna, M. V., Steffen, A., Boon, M., Chio, E., Copper, M., Patil, R. D., Green, K., Hanson, R., Heiser, C., Huntley, C., Kent, D., Larsen, C., Manchanda, S., Maurer, J. T., Soose, R., de Vries, N., Walia, H. K., Thaler, E., & ADHERE Registry Investigators (2021). Impact of Body Mass Index and Discomfort on Upper Airway Stimulation: ADHERE Registry 2020 Update. The Laryngoscope, 131(11), 2616–2624. https://doi.org/10.1002/lary.29755

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

34626128

Department(s)

Administration and Leadership

Document Type

Article