Importance of time to ON versus wearing OFF in total daily OFF time experienced by patients with Parkinson's disease.
Publication/Presentation Date
9-1-2023
Abstract
Most patients with Parkinson's disease (PD) receiving levodopa (LD)/DOPA decarboxylase inhibitors develop motor fluctuations with an increasing amount of OFF time, negatively impacting patient quality of life. Herein, we review the evidence supporting the substantial, yet underappreciated contribution of delays in time to ON (including delayed ON and no ON) to total daily OFF time. Most clinical studies use patient diaries that do not capture time to ON and wearing OFF separately as related to LD dosing, and consequently, most OFF time has generally been attributed to wearing OFF. Hence, most treatment regimens focus on reducing wearing OFF by changing LD dosing/formulations and/or using "ON-extenders" (eg, catechol-o-methyltransferase inhibitors, monoamine oxidase-B inhibitors, extended-release amantadine, and adenosine A
Volume
114
First Page
105495
Last Page
105495
ISSN
1873-5126
Published In/Presented At
Isaacson, S. H., Kremens, D., Torres-Yaghi, Y., Stocchi, F., & Antonini, A. (2023). Importance of time to ON versus wearing OFF in total daily OFF time experienced by patients with Parkinson's disease. Parkinsonism & related disorders, 114, 105495. https://doi.org/10.1016/j.parkreldis.2023.105495
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
37517986
Department(s)
Administration and Leadership
Document Type
Article