Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS.
Publication/Presentation Date
1-1-2010
Abstract
OBJECTIVE: To evaluate the effect of drug-resistant cytomegalovirus (CMV) on survival among patients with CMV retinitis.
DESIGN: Prospective cohort study during 1993 to 2003.
PARTICIPANTS: We included 266 patients with AIDS and newly diagnosed CMV retinitis treated with either ganciclovir or foscarnet.
METHODS: Data on ganciclovir and foscarnet resistance were obtained from blood and urine specimens collected at regular, predetermined intervals. The effect of resistant CMV on mortality was evaluated with a time-dependent Cox proportional hazard model.
MAIN OUTCOME MEASURES: Mortality.
RESULTS: The median survival of the entire cohort was 12.6 months. Analysis of risk factors for mortality demonstrated that resistant CMV was associated with an increased mortality (hazard ratio, 1.65; 95% confidence interval, 1.05-2.56; P = 0.032). Among the other parameters tested, only time since AIDS diagnosis was associated significantly with mortality, with a hazard ratio of 1.10 per year since AIDS diagnosis (P = 0.001).
CONCLUSIONS: Resistant CMV is associated with increased mortality among patients with AIDS being treated for CMV retinitis.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
Volume
117
Issue
1
First Page
128
Last Page
132
ISSN
1549-4713
Published In/Presented At
Jabs, D. A., Martin, B. K., Forman, M. S., & Cytomegalovirus Retinitis and Viral Resistance Research Group (2010). Mortality associated with resistant cytomegalovirus among patients with cytomegalovirus retinitis and AIDS. Ophthalmology, 117(1), 128–132.e2. https://doi.org/10.1016/j.ophtha.2009.06.016
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
19818505
Department(s)
Administration and Leadership
Document Type
Article