T cell subsets and cytomegalovirus retinitis in human immunodeficiency virus-infected patients.
Publication/Presentation Date
9-1-1997
Abstract
A case-control study was done to investigate the relationship between T cell subsets and cytomegalovirus (CMV) retinitis in human immunodeficiency virus (HIV)-infected subjects with or without CMV retinitis and CD4+ cell counts of < 0.050 x 10(9)/L. Cell surface markers on peripheral blood lymphocytes were evaluated using flow cytometry. Patients with CMV retinitis had significantly lower levels of CD8+ cells (median: 0.152 x 10(9)/L) compared with levels for controls (median: 0.296 x 10(9)/L, P < .001). Significant down-regulation of costimulatory molecule CD28+ and lymphocyte function-associated antigen-1 (LFA-1) expression was observed in patients versus controls (CD28+: 0.048 x 10(9)/L vs. 0.143 x 10(9)/L, P < .001; LFA-1: 0.238 x 10(9)/L vs. 0.400 x 10(9)/L, P < .001), but no significant differences were noted for NK cells. We propose that progressive loss of the CD3+ CD8+ cell subset and down-regulation of CD28 and LFA-1 accessory molecules are associated with an increased risk of CMV retinitis in HIV-infected patients.
Volume
176
Issue
3
First Page
790
Last Page
794
ISSN
0022-1899
Published In/Presented At
Tay-Kearney, M. L., Enger, C., Semba, R. D., Royal, W., 3rd, Dunn, J. P., & Jabs, D. A. (1997). T cell subsets and cytomegalovirus retinitis in human immunodeficiency virus-infected patients. The Journal of infectious diseases, 176(3), 790–794. https://doi.org/10.1086/517303
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
9291335
Department(s)
Administration and Leadership
Document Type
Article