Wide-field retinal imaging in the management of noninfectious posterior uveitis.
Publication/Presentation Date
11-1-2012
Abstract
PURPOSE: To determine whether the use of ultra wide-field imaging changes the management or determination of disease activity in patients with noninfectious posterior uveitis.
DESIGN: Prospective, observational case series.
METHODS: setting: Divisions of Retina and Ocular Immunology at single academic medical center. patient population: Total of 43 patients with noninfectious posterior uveitis seen by 4 investigators at the Wilmer Eye Institute. procedures: Each patient underwent standard clinical examination, followed by ultra wide-field scanning laser ophthalmoscope (SLO) imaging and angiography. Investigators successively determined disease activity and management decisions based on clinical examination, examination plus simulated 30- or 60-degree fluorescein angiography (FA) (obtained by physically narrowing the field of view of the wide-field images), examination plus ultra wide-field SLO images, and examination plus wide-field FA. main outcome measures: The primary outcome was the percentage of patients whose management changed based on the availability of wide-field imaging, compared with standard examination and imaging. The secondary outcome was detection of disease activity with and without wide-angle imaging.
RESULTS: Management was altered in 7 of 43 patients (16%) based on examination and limited FA, whereas 21 of 43 patients (48%) had management change with the use of the ultra wide-field imaging and angiography (P < .001). Disease activity was detected in 22 of 43 patients (51%) based on examination and simulated conventional imaging, and in 27 of 43 (63%) with wide-field imaging (P = .27).
CONCLUSIONS: The index study, with several design limitations, has suggested that ultra wide-field imaging may alter management decisions compared to standard-of-care imaging and clinical examination. Additional studies, including longitudinal evaluations, are needed to determine whether these findings, or the subsequent management alterations, may improve patient outcomes.
Volume
154
Issue
5
First Page
908
Last Page
911
ISSN
1879-1891
Published In/Presented At
Campbell, J. P., Leder, H. A., Sepah, Y. J., Gan, T., Dunn, J. P., Hatef, E., Cho, B., Ibrahim, M., Bittencourt, M., Channa, R., Do, D. V., & Nguyen, Q. D. (2012). Wide-field retinal imaging in the management of noninfectious posterior uveitis. American journal of ophthalmology, 154(5), 908–911.e2. https://doi.org/10.1016/j.ajo.2012.05.019
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22935598
Department(s)
Administration and Leadership
Document Type
Article