Cytomegalovirus retinitis and viral resistance. Prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group.

Authors

• D A Jabs
• J P Dunn
• C Enger
• M Forman
• N Bressler
• P Charache

Publication/Presentation Date

7-1-1996

Abstract

OBJECTIVE: To determine the prevalence of cytomegalovirus (CMV) isolates resistant to ganciclovir sodium or foscarnet sodium at the time of diagnosis of CMV retinitis, prior to the initiation of therapy.

DESIGN: Prospective epidemiologic study.

SETTING: An acquired immunodeficiency syndrome ophthalmology clinic.

PATIENTS: Patients with acquired immunodeficiency syndrome and newly diagnosed CMV retinitis.

INTERVENTION: Culturing blood and urine samples for CMV and testing of all positive isolates for sensitivity to ganciclovir and foscarnet.

MAIN OUTCOME MEASURE: Prevalence of the following: blood culture isolates resistant to ganciclovir (inhibitory concentration 50% [IC50] > 5.5 mumol/L) or foscarnet (IC50 > 400 mumol/L) and urine culture isolates resistant to ganciclovir or foscarnet.

RESULTS: Forty-nine patients were enrolled during a 13-month period. Forty-four patients had blood culture samples that could be evaluated; of these, 66% were positive (59% of patients). Thirty-four patients had urine cultures that were evaluable; of these, 82% were positive (57% of patients). Overall, 78% of patients had either a urine or blood culture sample positive for CMV. No blood culture isolates were resistant to ganciclovir, and only 1 urine culture isolate (2% of patients) was resistant to ganciclovir. Three percent of blood culture isolates and 4% of urine culture isolates (2% and 2% of patients, respectively) were resistant to foscarnet. Overall, 4% of patients had either a blood or urine culture isolate resistant to foscarnet.

CONCLUSION: Resistance to ganciclovir or foscarnet at the time of diagnosis of CMV retinitis is uncommon.

Volume

114

Issue

7

First Page

809

Last Page

814

ISSN

0003-9950

Published In/Presented At

Jabs, D. A., Dunn, J. P., Enger, C., Forman, M., Bressler, N., & Charache, P. (1996). Cytomegalovirus retinitis and viral resistance. Prevalence of resistance at diagnosis, 1994. Cytomegalovirus Retinitis and Viral Resistance Study Group. Archives of ophthalmology (Chicago, Ill. : 1960), 114(7), 809–814. https://doi.org/10.1001/archopht.1996.01100140023002

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

8660163

Department(s)

Administration and Leadership

Document Type

Article