Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial.
Publication/Presentation Date
4-1-2012
Abstract
PURPOSE: To assess the prevalence of hypotony in patients with severe forms of uveitis.
METHODS: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified.
RESULTS: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR] = 5.0; p < .01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR = 3.1; p = .03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. < 51 years, OR = 0.1; p = .02), in Caucasian patients (OR = 0.1; p < .01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR = 22.9; p < .01).
CONCLUSIONS: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.
Volume
20
Issue
2
First Page
104
Last Page
112
ISSN
1744-5078
Published In/Presented At
Sen, H. N., Drye, L. T., Goldstein, D. A., Larson, T. A., Merrill, P. T., Pavan, P. R., Sheppard, J. D., Burke, A., Srivastava, S. K., Jabs, D. A., & Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group (2012). Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial. Ocular immunology and inflammation, 20(2), 104–112. https://doi.org/10.3109/09273948.2011.647228
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
22409563
Department(s)
Administration and Leadership
Document Type
Article