Standalone Endovascular Embolization versus Stereotactic Radiosurgery in the Treatment of Arteriovenous Malformations in Eloquent Brain.

Publication/Presentation Date

10-1-2025

Abstract

Background Arteriovenous malformations (AVMs) in eloquent brain regions pose significant challenges due to the increased risk of neurologic deficits associated with treatment. Although stereotactic radiosurgery (SRS) and endovascular embolization are used as standalone approaches, their comparative outcomes in eloquent brain AVMs remain unclear. Purpose To directly compare the outcomes of standalone endovascular embolization versus SRS for patients with AVMs in the eloquent brain. Materials and Methods This retrospective multicenter study analyzed patients with AVMs located in eloquent brain regions treated with standalone SRS or embolization from January 2010 to December 2023 as part of the Multicenter International Study for Treatment of Brain AVMs, or MISTA, consortium. Angiographic outcomes were assessed using digital subtraction arterial angiography, MR angiography, or CT angiography. Propensity score weighting (PSW) was used to account for baseline differences. Results A total of 119 patients were included (median age, 35 years [IQR, 21-54 years]; 64 female), with 96 patients treated with SRS and 23 with embolization. SRS achieved 71% (61 of 86 patients) complete obliteration at last follow-up compared with 56% (10 of 18 patients) in the embolization group (odds ratio [OR], 1.95;

Volume

317

Issue

1

First Page

250329

Last Page

250329

ISSN

1527-1315

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

41117652

Department(s)

Administration and Leadership

Document Type

Article

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