Antigalactocerebroside serum demyelinates optic nerve in vivo.
Publication/Presentation Date
6-1-1984
Abstract
Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.
Volume
64
Issue
3
First Page
297
Last Page
303
ISSN
0022-510X
Published In/Presented At
Sergott, R. C., Brown, M. J., Silberberg, D. H., & Lisak, R. P. (1984). Antigalactocerebroside serum demyelinates optic nerve in vivo. Journal of the neurological sciences, 64(3), 297–303. https://doi.org/10.1016/0022-510x(84)90177-1
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
6470740
Department(s)
Administration and Leadership
Document Type
Article