Remyelination follows antibody-induced central nervous system demyelination.
Publication/Presentation Date
7-1-1986
Abstract
Remyelination after anti-galactocerebroside-induced demyelination in the guinea pig optic nerve was evident 17 days after the onset of demyelination. The tempo of remyelination was uniform for large- and small-diameter axons and progressed, with compaction and thickening of myelin sheaths. Demyelinated axons were found interspersed among remyelinated fibers and were consistently separated from oligodendrocytes by astrocytic processes. These findings indicate that central nervous system remyelination may occur after in vivo antibody-induced demyelination, but that new myelin formation may be limited by mechanical interference from astrocytic processes.
Volume
20
Issue
1
First Page
94
Last Page
98
ISSN
0364-5134
Published In/Presented At
Sergott, R. C., Brown, M. J., & Silberberg, D. H. (1986). Remyelination follows antibody-induced central nervous system demyelination. Annals of neurology, 20(1), 94–98. https://doi.org/10.1002/ana.410200117
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
3740817
Department(s)
Administration and Leadership
Document Type
Article