T-lymphocyte subpopulations in acute unilateral optic neuritis.
Publication/Presentation Date
7-1-1989
Abstract
The authors prospectively analyzed T-lymphocyte subpopulations in the peripheral blood of nine patients with acute unilateral optic neuritis and compared them with 25 controls without neurologic disease. The presence or absence of alterations in circulating T-cell subsets has not been examined previously in patients with isolated optic neuritis. The authors found the mean ratio of inducer (CD4) to suppressor (CD8) T-lymphocytes was 2.07 +/- 0.51 for the group with optic neuritis, statistically indistinguishable from a value of 1.78 +/- 1.04 for the control group. Multiple sclerosis (MS) subsequently developed in one patient. Her inducer/suppressor T-cell ratio was initially 2.66, but progressively increased to 3.68 concomitant with the clinical manifestation of focal neurologic signs. Although optic neuritis may be the initial clinical sign of MS, the periodic alteration of circulating T-lymphocytes increasing the inducer/suppressor T-cell ratio in MS was not observed in those with isolated optic neuritis.
Volume
96
Issue
7
First Page
1054
Last Page
1057
ISSN
0161-6420
Published In/Presented At
Guy, J. R., Feldberg, N. T., Savino, P. J., Schatz, N. J., & Sergott, R. C. (1989). T-lymphocyte subpopulations in acute unilateral optic neuritis. Ophthalmology, 96(7), 1054–1057. https://doi.org/10.1016/s0161-6420(89)32792-8
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2570391
Department(s)
Administration and Leadership
Document Type
Article