Antibody to myelin-associated glycoprotein produces central nervous system demyelination.
Publication/Presentation Date
3-1-1988
Abstract
Antibodies to myelin-associated glycoprotein (MAG) have been implicated in certain human demyelinating diseases of the peripheral nervous system. In the present study, a monoclonal antibody to MAG with 20% guinea pig serum (GPS) was injected into mammalian optic nerves and produced in vivo demyelination associated with three ultrastructural patterns of myelin injury: (1) widened lamellae; (2) myelin vesiculation; and (3) cell-associated myelin damage. These patterns of myelin injury have been observed neuropathologically in MS and in a demyelinating peripheral neuropathy associated with plasma cell dyscrasias. Demyelination was not observed in nerves injected with anti-MAG and heated GPS or a monoclonal antibody to chick myoblasts and 20% GPS. These results establish the ability of anti-MAG to produce in vivo demyelination of mammalian CNS and indicate that a single antibody directed against a specific myelin component may initiate multiple types of myelin damage.
Volume
38
Issue
3
First Page
422
Last Page
426
ISSN
0028-3878
Published In/Presented At
Sergott, R. C., Brown, M. J., Lisak, R. P., & Miller, S. L. (1988). Antibody to myelin-associated glycoprotein produces central nervous system demyelination. Neurology, 38(3), 422–426. https://doi.org/10.1212/wnl.38.3.422
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
2450303
Department(s)
Administration and Leadership
Document Type
Article