Optic nerve demyelination induced by human serum: patients with multiple sclerosis or optic neuritis and normal subjects.
Publication/Presentation Date
10-1-1985
Abstract
We injected guinea pig optic nerves with serum from patients with MS or acute optic neuritis (ON), or normal subjects. Serum from 12 of 17 MS patients, 3 of 3 patients with ON, and 5 of 11 normal age- and sex-matched controls produced myelin vesiculation and demyelination 24 hours after injection. Nerves injected with demyelinating serum contained oligodendrocytes with pyknotic nuclei and edematous, rarefied cytoplasm. Nerves injected with serum that did not cause demyelination did not have these oligodendrocyte changes. Serum from normal subjects or patients with MS may induce in vivo demyelination in mammalian CNS.
Volume
35
Issue
10
First Page
1438
Last Page
1442
ISSN
0028-3878
Published In/Presented At
Sergott, R. C., Brown, M. J., Polenta, R. M., Lisak, R. P., & Silberberg, D. H. (1985). Optic nerve demyelination induced by human serum: patients with multiple sclerosis or optic neuritis and normal subjects. Neurology, 35(10), 1438–1442. https://doi.org/10.1212/wnl.35.10.1438
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
4033926
Department(s)
Administration and Leadership
Document Type
Article