Optic-nerve gliomas, chiasmal gliomas and neurofibromatosis type 1.
Publication/Presentation Date
2-1-2006
Abstract
PURPOSE OF REVIEW: To review the most recent literature describing the natural history and disease progression patterns of optic-pathway gliomas in neurofibromatosis type 1 (NF1) patients. To aid in clarifying the current treatment patterns and follow-up recommendations.
RECENT FINDINGS: Contrary to prior documentation, current literature reveals that optic-pathway gliomas in NF1 can be diagnosed after the age of 6, and may progress until the age of 12. The disease progression occurs most frequently in the first two years following diagnosis.
SUMMARY: Optic-pathway gliomas in NF1 can display a variety of manifestations and exhibit an unpredictable disease course. No specific characteristics have been found thus far to predict an aggressive compared with indolent disease course. Recently primary diagnoses of optic-pathway gliomas have been made in children aged six or older, and have been shown to progress until the age of 12. Although large-scale studies are required to change current follow-up recommendations, the data suggest that NF1 patients should be vigilantly evaluated for optic-pathway gliomas past the age of 12.
Volume
17
Issue
1
First Page
7
Last Page
11
ISSN
1040-8738
Published In/Presented At
Sylvester, C. L., Drohan, L. A., & Sergott, R. C. (2006). Optic-nerve gliomas, chiasmal gliomas and neurofibromatosis type 1. Current opinion in ophthalmology, 17(1), 7–11. https://doi.org/10.1097/01.icu.0000193070.32369.37
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
16436918
Department(s)
Administration and Leadership
Document Type
Article