Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy? New evidence from genetic analysis.
Publication/Presentation Date
12-1-2002
Abstract
Normal tension glaucoma and dominant optic atrophy share many overlapping clinical features, and differentiating between these two diseases is often difficult. The gene responsible for dominant optic atrophy is the OPA1 gene located on chromosome 3. This gene encodes for a protein product that is involved in mitochondrial metabolic function. Recent genetic linkage analysis of patients with normal tension glaucoma has shown an association with polymorphisms of the OPA1 gene. This association suggests that normal tension glaucoma may actually be a hereditary optic neuropathy with a pathophysiology based in mitochondrial dysfunction.
Volume
13
Issue
6
First Page
362
Last Page
370
ISSN
1040-8738
Published In/Presented At
Buono, L. M., Foroozan, R., Sergott, R. C., & Savino, P. J. (2002). Is normal tension glaucoma actually an unrecognized hereditary optic neuropathy? New evidence from genetic analysis. Current opinion in ophthalmology, 13(6), 362–370. https://doi.org/10.1097/00055735-200212000-00004
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
12441838
Department(s)
Administration and Leadership
Document Type
Article