Partial versus radical nephrectomy for complex renal mass: multicenter comparative analysis of functional outcomes (Rosula collaborative group).

Authors

• Clara Cerrato
• Margaret F Meagher
• Riccardo Autorino
• Giuseppe Simone
• Bo Yang
• Robert G Uzzo
• Alexander Kutikov
• Francesco Porpiglia
• Umberto Capitanio
• Francesco Montorsi
• James Porter
• Alp T Beksac
• Dhruv Puri
• Mimi Nguyen
• Luke Wang
• Kevin Hakimi
• Sohail Dhanji
• Franklin Liu
• Maria A Cerruto
• Savio D Pandolfo
• Andrea Minervini
• Clayton Lau
• Aron Monish
• Daniel Eun
• Alexandre Mottrie
• Carmen Mir
• Chandru Sundaram
• Alessandro Antonelli
• Jihad Kaouk
• Ithaar H Derweesh

Publication/Presentation Date

8-1-2023

Abstract

BACKGROUND: Utility of partial nephrectomy (PN) for complex renal mass (CRM) is controversial. We determined the impact of surgical modality on postoperative renal functional outcomes for CRM.

METHODS: We retrospectively analyzed a multicenter registry (ROSULA). CRM was defined as RENAL Score 10-12. The cohort was divided into PN and radical nephrectomy (RN) for analyses. Primary outcome was development of de-novo estimated glomerular filtration rate (eGFR)< 45 mL/min/1.73 m

RESULTS: We analyzed 969 patients (RN=429/PN=540; median follow-up 24.0 months). RN patients had lower BMI (P< 0.001) and larger tumor size (P< 0.001). Overall postoperative complication rate was higher for PN (P< 0.001), but there was no difference in major complications (Clavien III-IV; P=0.702). MVA demonstrated age (HR=1.05, P< 0.001), tumor-size (HR=1.05, P=0.046), RN (HR=2.57, P< 0.001), and BMI (HR=1.04, P=0.001) to be associated with risk for de-novo eGFR< 60 mL/min/1.73 m

CONCLUSIONS: PN provides functional benefit in selected patients with CRM without significant increase in major complications compared to RN, and should be considered when technically feasible.

Volume

75

Issue

4

First Page

425

Last Page

433

ISSN

2724-6442

Published In/Presented At

Cerrato, C., Meagher, M. F., Autorino, R., Simone, G., Yang, B., Uzzo, R. G., Kutikov, A., Porpiglia, F., Capitanio, U., Montorsi, F., Porter, J., Beksac, A. T., Puri, D., Nguyen, M., Wang, L., Hakimi, K., Dhanji, S., Liu, F., Cerruto, M. A., Pandolfo, S. D., … Derweesh, I. H. (2023). Partial versus radical nephrectomy for complex renal mass: multicenter comparative analysis of functional outcomes (Rosula collaborative group). Minerva urology and nephrology, 75(4), 425–433. https://doi.org/10.23736/S2724-6051.23.05123-6

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

37530659

Department(s)

Administration and Leadership

Document Type

Article