Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis.
Publication/Presentation Date
4-1-2015
Abstract
Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.
Volume
22
Issue
2
First Page
7755
Last Page
7757
ISSN
1488-5581
Published In/Presented At
Norberg, S. M., Oros, M., Manucha, V., Eun, D., & Bilusic, M. (2015). Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis. The Canadian journal of urology, 22(2), 7755–7757.
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25891343
Department(s)
Administration and Leadership
Document Type
Article