Hypothermic machine preservation in human liver transplantation: the first clinical series.

Authors

• J V Guarrera
• S D Henry
• B Samstein
• R Odeh-Ramadan
• M Kinkhabwala
• M J Goldstein
• L E Ratner
• J F Renz
• H T Lee
• R S Brown
• J C Emond

Publication/Presentation Date

2-1-2010

Abstract

Hypothermic machine perfusion (HMP) is widely used to preserve kidneys for transplantation with improved results over cold storage (CS). To date, successful transplantation of livers preserved with HMP has been reported only in animal models. In this, the first prospective liver HMP study, 20 adults received HMP-preserved livers and were compared to a matched group transplanted with CS livers. HMP was performed for 3-7 h using centrifugal perfusion with Vasosol solution at 4-6 degrees C. There were no cases of primary nonfunction in either group. Early allograft dysfunction rates were 5% in the HMP group versus 25% in controls (p = 0.08). At 12 months, there were two deaths in each group, all unrelated to preservation or graft function. There were no vascular complications in HMP livers. Two biliary complications were observed in HMP livers compared with four in the CS group. Serum injury markers were significantly lower in the HMP group. Mean hospital stay was shorter in the HMP group (10.9 +/- 4.7 days vs. 15.3 +/- 4.9 days in the CS group, p = 0.006). HMP of donor livers provided safe and reliable preservation in this pilot case-controlled series. Further multicenter HMP trials are now warranted.

Volume

10

Issue

2

First Page

372

Last Page

381

ISSN

1600-6143

Published In/Presented At

Guarrera, J. V., Henry, S. D., Samstein, B., Odeh-Ramadan, R., Kinkhabwala, M., Goldstein, M. J., Ratner, L. E., Renz, J. F., Lee, H. T., Brown, R. S., Jr, & Emond, J. C. (2010). Hypothermic machine preservation in human liver transplantation: the first clinical series. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 10(2), 372–381. https://doi.org/10.1111/j.1600-6143.2009.02932.x

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

19958323

Department(s)

Administration and Leadership

Document Type

Article