"Resuscitation" of marginal liver allografts for transplantation with machine perfusion technology.
Publication/Presentation Date
8-1-2014
Abstract
As the rate of medically suitable donors remains relatively static worldwide, clinicians have looked to novel methods to meet the ever-growing demand of the liver transplant waiting lists worldwide. Accordingly, the transplant community has explored many strategies to offset this deficit. Advances in technology that target the ex vivo "preservation" period may help increase the donor pool by augmenting the utilization and improving the outcomes of marginal livers. Novel ex vivo techniques such as hypothermic, normothermic, and subnormothermic machine perfusion may be useful to "resuscitate" marginal organs by reducing ischemia/reperfusion injury. Moreover, other preservation techniques such as oxygen persufflation are explored as they may also have a role in improving function of "marginal" liver allografts. Currently, marginal livers are frequently discarded or can relegate the patient to early allograft dysfunction and primary non-function. Bench to bedside advances are rapidly emerging and hold promise for expanding liver transplantation access and improving outcomes.
Volume
61
Issue
2
First Page
418
Last Page
431
ISSN
1600-0641
Published In/Presented At
Graham, J. A., & Guarrera, J. V. (2014). "Resuscitation" of marginal liver allografts for transplantation with machine perfusion technology. Journal of hepatology, 61(2), 418–431. https://doi.org/10.1016/j.jhep.2014.04.019
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
24768755
Department(s)
Administration and Leadership
Document Type
Article