Hypothermic machine preservation facilitates successful transplantation of "orphan" extended criteria donor livers.
Publication/Presentation Date
1-1-2015
Abstract
Hypothermic machine preservation (HMP) remains investigational in clinical liver transplantation. It is widely used to preserve kidneys for transplantation with improved results over static cold storage (SCS). At our center, we have used HMP in 31 adults receiving extended criteria donor (ECD) livers declined by the originating United Network for Organ Sharing region ("orphan livers"). These cases were compared to ECD SCS cases in a matched cohort study design. Livers were matched for donor age, recipient age, cold ischemic time, donor risk index and Model for End-Stage Liver Disease (MELD) score. HMP was performed for 3-7 h at 4-8 °C using our previously published protocol. Early allograft dysfunction rates were 19% in the HMP group versus 30% in the control group (p = 0.384). One-year patient survival was 84% in the HMP group versus 80% in the SCS group (p = NS). Post hoc analysis revealed significantly less biliary complications in the HMP group versus the SCS group (4 vs. 13, p = 0.016). Mean hospital stay was significantly shorter in the HMP group (13.64 ± 10.9 vs. 20.14 ± 11.12 days in the SCS group, p = 0.001). HMP provided safe and reliable preservation in orphan livers transplanted at our center.
Volume
15
Issue
1
First Page
161
Last Page
169
ISSN
1600-6143
Published In/Presented At
Guarrera, J. V., Henry, S. D., Samstein, B., Reznik, E., Musat, C., Lukose, T. I., Ratner, L. E., Brown, R. S., Jr, Kato, T., & Emond, J. C. (2015). Hypothermic machine preservation facilitates successful transplantation of "orphan" extended criteria donor livers. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(1), 161–169. https://doi.org/10.1111/ajt.12958
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
25521639
Department(s)
Administration and Leadership
Document Type
Article