Novel oxygenation technique for hypothermic machine perfusion of liver grafts: Validation in porcine Donation after Cardiac Death (DCD) liver model.

Authors

• Guergana G Panayotova
• Jesus Rosado
• Flavio Paterno
• Dayanand Deo
• George Dikdan
• Matthew A McCarty
• Ben Arrington
• Anthony Giudice
• Adam Fano
• Nehal Dhaduk
• Keri E Lunsford
• Prakash Rao
• James V Guarrera

Publication/Presentation Date

11-1-2020

Abstract

BACKGROUND: Hypothermic oxygenated machine perfusion improves outcomes in Liver Transplantation, but application is limited as O

METHODS: Porcine DCD livers were randomized to static cold storage (SCS, n = 8) or hypothermic machine perfusion (HMP). HMP was stratified into HMP-O

RESULTS: "Pre-charge" achieves sustained tissue and perfusate pO

CONCLUSIONS: "Pre-charge" is an effective technique, which allows portability and transport without an O

Volume

220

Issue

5

First Page

1270

Last Page

1277

ISSN

1879-1883

Published In/Presented At

Panayotova, G. G., Rosado, J., Paterno, F., Deo, D., Dikdan, G., McCarty, M. A., Arrington, B., Giudice, A., Fano, A., Dhaduk, N., Lunsford, K. E., Rao, P., & Guarrera, J. V. (2020). Novel oxygenation technique for hypothermic machine perfusion of liver grafts: Validation in porcine Donation after Cardiac Death (DCD) liver model. American journal of surgery, 220(5), 1270–1277. https://doi.org/10.1016/j.amjsurg.2020.06.072

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

32892979

Department(s)

Administration and Leadership

Document Type

Article