Hypothermic machine perfusion in liver transplantation.
Publication/Presentation Date
10-1-2020
Abstract
Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs, hypothermic perfusion is mainly used for a relatively short period with protection of mitochondria and subsequent reduction of oxidative injury upon implantation. The results from two randomized controlled trials, where recruitment has finished are expected this year. Both ex situ perfusion techniques are increasingly applied in clinical transplantation including recent reports on viability assessment, which could open the door for an increased liver utilization in the future.
Volume
82S
First Page
44
Last Page
51
ISSN
1743-9159
Published In/Presented At
Karangwa, S., Panayotova, G., Dutkowski, P., Porte, R. J., Guarrera, J. V., & Schlegel, A. (2020). Hypothermic machine perfusion in liver transplantation. International journal of surgery (London, England), 82S, 44–51. https://doi.org/10.1016/j.ijsu.2020.04.057
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
32353556
Department(s)
Administration and Leadership
Document Type
Article