Impersistence of depression in youth: Implications for drug study design.
Publication/Presentation Date
9-1-2006
Abstract
Food and Drug Administration data show that most anti-depressant studies in youth do not show drug effect. The few positive studies used rigorous diagnostic screening procedures, suggesting major depressive disorder (MDD) may not be a persistent condition in a subgroup of youth. To investigate persistence of MDD, we serially assessed a cohort of inpatients admitted to the hospital with a clinical diagnosis of MDD. Assessments included a structured diagnostic interview, the Diagnostic Interview for Children and Adolescents-Revised (DICA-R), and measures of depressive symptomatology. Of 66 subjects (40 girls; mean age, 14.4 +/- 2.2 years), 34 (51.5%) met DICA-R criteria for MDD at the initial postadmission assessment. Of these, only 8 (23.5%) met DICA-R criteria for MDD at any subsequent assessment. Similar reductions were found on other ratings of depression. In conclusion, MDD did not persist in this sample. The findings suggest a multigated assessment procedure should be employed before randomization in antidepressant clinical trials.
Volume
46
Issue
9
First Page
1044
Last Page
1051
ISSN
0091-2700
Published In/Presented At
Malone, R. P., Bennett, D. S., Delaney, M. A., Choudhury, M. S., Luebbert, J. F., & Cater, J. (2006). Impersistence of depression in youth: Implications for drug study design. Journal of clinical pharmacology, 46(9), 1044–1051. https://doi.org/10.1177/0091270006290334
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
16920900
Department(s)
Administration and Leadership
Document Type
Article