Previous Surgery and Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea.

Authors

• Eric J Kezirian
• Clemens Heiser
• Armin Steffen
• Maurits Boon
• Benedikt Hofauer
• Karl Doghramji
• Joachim T Maurer
• J Ulrich Sommer
• Ryan J Soose
• Richard Schwab
• Erica Thaler
• Kirk Withrow
• Alan Kominsky
• Christopher G Larsen
• Jennifer Hsia
• Reena Mehra
• Tina Waters
• Kingman Strohl

Publication/Presentation Date

11-1-2019

Abstract

OBJECTIVE: To examine whether previous palate or hypopharyngeal surgery was associated with efficacy of treatment of obstructive sleep apnea with hypoglossal nerve stimulation.

STUDY DESIGN: Cohort (retrospective and prospective).

SETTING: Eleven academic medical centers.

SUBJECTS AND METHODS: Adults treated with hypoglossal nerve stimulation were enrolled in the ADHERE Registry. Outcomes were defined by the apnea-hypopnea index (AHI), in 3 ways: change in the AHI and 2 definitions of therapy response requiring ≥50% reduction in the AHI to a level < 20 events/h (Response20) or 15 events/h (Response15). Previous palate and hypopharyngeal (tongue, epiglottis, or maxillofacial) procedures were documented. Linear and logistic regression examined the association between previous palate or hypopharyngeal surgery and outcomes, with adjustment for age, sex, and body mass index.

RESULTS: The majority (73%, 217 of 299) had no previous palate or hypopharyngeal surgery, while 25% and 9% had previous palate or hypopharyngeal surgery, respectively, including 6% with previous palate and hypopharyngeal surgery. Baseline AHI (36.0 ± 15.6 events/h) decreased to 12.0 ± 13.3 at therapy titration (

CONCLUSION: Previous upper airway surgery was not clearly associated with efficacy of hypoglossal nerve stimulation.

Volume

161

Issue

5

First Page

897

Last Page

903

ISSN

1097-6817

Published In/Presented At

Kezirian, E. J., Heiser, C., Steffen, A., Boon, M., Hofauer, B., Doghramji, K., Maurer, J. T., Sommer, J. U., Soose, R. J., Schwab, R., Thaler, E., Withrow, K., Kominsky, A., Larsen, C. G., Hsia, J., Mehra, R., Waters, T., & Strohl, K. (2019). Previous Surgery and Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 161(5), 897–903. https://doi.org/10.1177/0194599819856339

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

31234734

Department(s)

Administration and Leadership

Document Type

Article