Neuroimaging findings in 4342 hospitalized COVID-19 subjects: A multicenter report from the United States and Europe.
Publication/Presentation Date
1-1-2023
Abstract
BACKGROUND AND PURPOSE: To determine the incidence of acute neuroimaging (NI) findings and comorbidities in the coronavirus disease of 2019 (COVID-19)-infected subjects in seven U.S. and four European hospitals.
METHODS: This is a retrospective study of COVID-19-positive subjects with the following inclusion criteria: age >18, lab-confirmed COVID-19 infection, and acute NI findings (NI+) attributed to COVID-19 on CT or MRI brain. NI+ and comorbidities in total hospitalized COVID-19-positive (TN) subjects were assessed.
RESULTS: A total of 37,950 COVID-19-positive subjects were reviewed and 4342 underwent NI. NI+ incidence in subjects with NI was 10.1% (442/4342) including 7.9% (294/3701) in the United States and 22.8% (148/647) in Europe. NI+ incidence in TN was 1.16% (442/37,950). In NI (4342), incidence of ischemic stroke was 6.4% followed by intracranial hemorrhage (ICH) (3.8%), encephalitis (0.5%), sinus venous thrombosis (0.2%), and acute disseminated encephalomyelitis (ADEM) (0.2%). White matter involvement was seen in 57% of NI+. Hypertension was the most common comorbidity (54%) before cardiac disease (28.8%) and diabetes mellitus (27.7%). Cardiac disease (p < .025), diabetes (p < .014), and chronic kidney disease (p < .012) were more common in the United States.
CONCLUSION: This multicenter, multinational study investigated the incidence and spectrum of NI+ in 37,950 hospitalized adult COVID-19 subjects including regional differences in incidences of NI+, associated comorbidities, and other demographics. NI+ incidence in TN was 1.16% including 0.95% in the United States and 2.09% in Europe. ICH, encephalitis, and ADEM were common in Europe, while ischemic strokes were more common in the United States. In this cohort, incidence and distribution of NI+ helped characterize the neurological complications of COVID-19.
Volume
33
Issue
5
First Page
752
Last Page
763
ISSN
1552-6569
Published In/Presented At
Faro, S. H., Manmatharayan, A., Leiby, B., Jain, N., Mohamed, F. B., Talekar, K. S., Doshi, A., Jambor, I., Chang, S., Finkelstein, M., Kremer, S., Lersy, F., Lindgren, B., Figueiredo, N. M., Gerevini, S., Napolitano, A., Jain, R., Dogra, S., Pillai, J. J., Ryan, D., … Pizzini, F. (2023). Neuroimaging findings in 4342 hospitalized COVID-19 subjects: A multicenter report from the United States and Europe. Journal of neuroimaging : official journal of the American Society of Neuroimaging, 33(5), 752–763. https://doi.org/10.1111/jon.13140
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
37381160
Department(s)
Administration and Leadership
Document Type
Article