Chronic neutrophilic leukaemia.
Publication/Presentation Date
9-1-2015
Abstract
Chronic neutrophilic leukaemia (CNL) is a rare type of myeloproliferative neoplasm (MPN) characterised by sustained leucocytosis (≥25×10(9)/L) with neoplastic proliferation of neutrophilic granulocytes in blood and bone marrow. In contrast to chronic myeloid leukaemia, the disease primarily involves neutrophilic lineage with persistent proliferation of mature forms of neutrophils. No consistent cytogenetic changes have been reported. Known recurrent genetic changes in other MPNs such as JAK2, MPL, CALR, BCR-ABL1, PDGFRA, PDGFRB and FGFR1 are mostly absent. Recently, mutations in colony stimulating factor 3 receptor (CSF3R) have been reported in high frequency in CNL. This discovery has provided more insight into its pathogenesis and opened up possible treatment options. In this article, we review the clinical findings, morphology, pathobiology and differential diagnosis of CNL and treatment implications of CSF3R mutations.
Volume
68
Issue
9
First Page
680
Last Page
684
ISSN
1472-4146
Published In/Presented At
Uppal, G., & Gong, J. (2015). Chronic neutrophilic leukaemia. Journal of clinical pathology, 68(9), 680–684. https://doi.org/10.1136/jclinpath-2015-203060
Disciplines
Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods
PubMedID
26082513
Department(s)
Administration and Leadership
Document Type
Article