Correlation of EZH2 and related signaling molecules p-STAT3, p-ERK1/2, and MYC overexpression with H3K27 trimethylation associates differently to disease progression in JAK2 mutation -positive and -negative myeloid neoplasms.

Authors

• Elizaveta Flerova
• Jiani Chai
• Jui Choudhuri
• Jerald Z Gong
• Yanhua Wang
• Xuejun Tian

Publication/Presentation Date

3-1-2026

Abstract

EZH2 is an important epigenetic regulator in malignant neoplasms. We investigated the tumorigenic roles of EZH2 and intracellular molecules in

Volume

67

Issue

4

First Page

832

Last Page

845

ISSN

1029-2403

Published In/Presented At

Flerova, E., Chai, J., Choudhuri, J., Gong, J. Z., Wang, Y., & Tian, X. (2026). Correlation of EZH2 and related signaling molecules p-STAT3, p-ERK1/2, and MYC overexpression with H3K27 trimethylation associates differently to disease progression in JAK2 mutation -positive and -negative myeloid neoplasms. Leukemia & lymphoma, 67(4), 832–845. https://doi.org/10.1080/10428194.2025.2609752

Disciplines

Business Administration, Management, and Operations | Health and Medical Administration | Management Sciences and Quantitative Methods

PubMedID

41474263

Department(s)

Administration and Leadership

Document Type

Article